Home  |  About  |  Contact  |  Join MCACS  Donate to MCACS
Massachusetts Chapter of the American College of Surgeons Massachusetts Chapter of the American College of Surgeons Massachusetts Chapter of the American College of Surgeons Massachusetts Chapter of the American College of Surgeons Massachusetts Chapter of the American College of Surgeons
57th Annual Meeting Abstracts


Poster 17

Abstract Title

Post-Bariatric Surgery Ethnic Differences In Alt Serum Levels: A Marker Of Visceral Adiposity

 

Author Block

Dimitrios Xourafas, MD, Ali Ardestani, MD, Stanley W. Ashley, MD, Ali Tavakkolizadeh, MD
Brigham and Women's Hospital/Harvard Medical School, Boston, MA

 

Abstract Body

Background: Many report that morbidly obese African-Americans have a lower incidence of progressive hepatic steatosis and NASH. Since serum ALT levels are associated with liver fat content, we compared baseline and post-operative ALT levels in the 3 major US ethnic groups, controlling for weight changes following bariatric procedures.

Methods: 743 patients undergoing bariatric surgery were included. Demographics and co-morbidities were documented. ALT and BMI were recorded pre and postoperatively and compared within and between different ethnic groups. ANOVA or Chi-square was used to evaluate outcomes.

Results: 503 Caucasians, 145 African-Americans and 95 Hispanics underwent Roux-en-Y gastric bypass or adjustable gastric banding surgeries. Groups were similar in terms of gender, BMI and comorbidities, including type II diabetes mellitus. At 1-year follow-up, all patients lost a significant and similar amount of weight, irrespective of ethnicity. Caucasians and Hispanics, had a statistically significant decrease in ALT. African-Americans had normal ALT at baseline(20 IU/dl), which did not change postoperatively despite significant weight loss(Table-1).

Conclusion: Race does not influence weigh loss after bariatric surgery. Caucasian and Hispanics have elevated baseline ALT which reduces post-operatively. African-Americans have normal baseline ALT, likely reflecting reduced incident of steatosis and NASH. Such levels do not change following surgery, despite significant weight loss, suggesting that multiple factors can regulate ALT serum levels. In African-Americans, ALT is not a good predictor of post-operative metabolic improvement.


 

BASELINE

1-YEAR

   P-VALUE

CAUCASIANS (n=503)

BMI

47.4

34.4

< 0.05

ALT

31.7

21.2

< 0.05

HISPANICS (n=95)

BMI

45.4

32.8

< 0.05

ALT

27.4

18.5

< 0.05

AFRICAN-AMERICANS (n=145)

BMI

48.6

35.9

< 0.05

ALT

20.7

20.7

=1


 

 Home | About | Contact